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KMID : 0358819860130010009
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Journal of Korean Society of Plastic and Reconstructive Surgeons
1986 Volume.13 No. 1 p.9 ~ p.12
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EFFECT OF NICOTINE ON BLOOD FLOW AND PATENCY OF EXPERIMENTAL MICROVASCULAR ANASTOMOSIS
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Lee Myung-Sun
Lee Sang-Heon
Lee Young-Ho
You Jae-Duk
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Abstract
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Nicotine is known to have deleterious effects on the cardiovascular system, causing vasoconstriction and increased blood pressure. A drop in bloodflow velocity in humans, endothelial damage in rats, and increase of platelet aggregation in rabbit’s blood have all been shown experimentally.
In this paper, two experimental works are described that investigate the effects of nicotine on microvascular anastomotic patency. In experiment 1, electromagnetic blood-flow recordings were made in the epigastric artery of the groin flap after intraarterial instillation of nicotine. Decreased blood flow was consistently recorded up to a maximum of 78% of normal flow.
In experiment 2, rat femoral arteries were anastomosed and the patency rate at three weeks checked after various combinations of pre-and postoperative intraperitoneal nicotine had been injected. There was no significant increase in thrombosis between the groups treated with nicotine and the control.
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KEYWORD
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